Journal article
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato, Susan N Christo, Raissa Fonseca, Simone L Park, Thomas N Burn, Maleika Osman, Sapna Devi, Jerold Chun, Scott N Mueller, George Kannourakis, Stuart P Berzins, Daniel G Pellicci, William R Heath, Stephen C Jameson, Laura K Mackay
JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 2021
DOI: 10.1084/jem.20210116
Abstract
Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the key events controlling TRM cell development is the local retention of TRM cell precursors coupled to downregulation of molecules necessary for tissue exit. Sphingosine-1-phosphate receptor 5 (S1PR5) is a migratory receptor with an uncharted function in T cells. Here, we show that S1PR5 plays a critical role in T cell infiltration and emigration from peripheral organs, as well as being specifically downregulated in TRM cells. Consequentially, TRM cell development was selectively impaired upon ectopic expression of S1pr5, whereas loss of S1pr5 enhanced skin TRM cell formation by promoting peripheral T cell ..
View full abstractGrants
Awarded by Bill and Melinda Gates Foundation International Research Scholarship
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by a Howard Hughes Medical In-stitute and Bill and Melinda Gates Foundation International Research Scholarship OPP1175796 to L.K. Mackay and Australian Research Council grant DP200102753 to L.K. Mackay and M. Evrard. M. Evrard is supported by the University of Melbourne McKenzie Postdoctoral Fellowship. S.L. Park is supported by a National Health and Medical Research Council Emerging Lead-ership Investigator grant. D.G. Pellicci is supported by a Com-monwealth Serum Laboratories Centenary Fellowship. L.K. Mackay is a senior medical research fellow supported by the Sylvia and Charles Viertel Charitable Foundation.